In this review, the authors summarize some of the evidence that implicates lactate in intercellular signaling in the brain. Lactate is one of the most common metabolites in the mammalian body and is produced in all cells including neurons and glia of the brain. Glycolysis leads to formation of pyruvate, part of which is converted into lactate by lactate dehydrogenase.
This review was written by Mosienko et al. under the original title “Is L-lactate a novel signaling molecule in the brain?”, and was published in 2015 by Journal of Cerebral Blood Flow & Metabolism.
In this article, Mosienko et al. summarize some of the current ideas about a signaling role of L-lactate in the brain. The proposed mechanisms either pivot around the intracellular fate of L-lactate (contribution to ATP production or change in NADH/NAD+ ratio induced by L-lactate to pyruvate conversion) or the existence of a designated receptor for L-lactate, a mechanism that does not require L-lactate entry into the target neuron.
More information available at Laktate.